Hartono, Hartono and Hazawa, Masaharu and Dewi, Firli Rahmah Primula and Kobayashi, Akiko and Mohamed, Mahmoud Shaaban and Wong, Richard W. (2018) The role of nucleoporin Nup58 during cell division. In: Tokyo 2018 Cell and Developmental Biology Meeting (the Joint Annual Meeting of 70th JSCB and 51st JSDB), 5-8 Juni 2018, Tokyo, Japan. (Unpublished)
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THE ROLE OF NUCLEOPORIN NUP58 DURING CELL DIVISION_2018_tokyo.pdf Download (4MB) |
Abstract
Nuclear pore complexes (NPCs) are transport channels between the nucleus and the cytoplasm. The NPCs are composed by around 30 different proteins, termed nucleoporins (Nups) and each Nup is present in multiple copies. Recently, we and others discovered that several nucleoporins play critical roles during cell division including chromosome condensation, sister chromatid cohesion, kinetochore assembly and spindle formation. Nup58 is a part of the central transport channel of the NPC, which forms a complex protein with other nucleoporins such as Nup62 and Nup54. Recently, we showed that Nup62 plays a novel role in centrosome integrity. Here, we show that Nup62 interacts with Nup58 during cell mitosis. Next, we performed RNA interference-mediated knockdown of Nup58. Currently, we are investigating Nup58 depletion effect in cell cycle.
| Item Type: | Conference or Workshop Item (Poster) |
|---|---|
| Subjects: | FMIPA |
| Divisions: | FAKULTAS MIPA |
| Depositing User: | Zainatun |
| Date Deposited: | 26 Jun 2023 06:45 |
| Last Modified: | 26 Jun 2023 06:45 |
| URI: | http://eprints.unm.ac.id/id/eprint/31399 |
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