Meroterpenoids produced by Pseudocosmospora sp. Bm-1-1 isolated from Acanthus ebracteatus Vahl

Nakamura, Tomoki and Suzuki, Takuma and Ariefta, Nanang Rudianto and Koseki, Takuya and Aboshi, Takako and Murayama, Tetsuya and Widiyantoro, Ari and Kurniatuhadi, Rikhsan and Malik, Abdul and Annas, Suwardi and Harneti, Desi and Maharani, Rani and Supratman, Unang and Abe, Junpei and Kurisawa, Naoaki and Kimura, Ken-ich and Shiono, Yoshihito (2019) Meroterpenoids produced by Pseudocosmospora sp. Bm-1-1 isolated from Acanthus ebracteatus Vahl. Phytochemistry Letters, 31. pp. 85-91. ISSN 1876-7486

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Official URL: https://linkinghub.elsevier.com/retrieve/pii/S1874...

Abstract

Fractionation of ethyl acetate extract obtained by culturing the endophytic fungus Pseudocosmospora sp. Bm-1-1 resulted in the isolation of four new meroterpenoids, cosmosporin A (1), 6-carboxy-cosmosporin A (2), rel-(6aS,10aR)-Δ9-tetrahydrocannabiorcolic acid B (3) and 8′-hydroxy-cannabiorcichromenic acid (4), in addition to four known compounds 5–8. Structures were elucidated by spectral analysis, as well as by directly comparing the spectral data of new compounds with those of known compounds. Cannabiorcichromenic acid (5), decarboxy-cannabiorcichromenic acid (6), and rel-(6aS,10aR)-decarboxy-Δ9-tetrahydrocannabiorcolic acid B (8) restored growth of a Saccharomyces cerevisiae mutant strain involving Ca2+ signal transduction. Furthermore, compounds 3 and 8 had cytotoxic activity against HL60 cells (3: IC50 = 24.1 μM and 8: IC50 1.6 μM).

Item Type:	Article
Subjects:	KARYA ILMIAH DOSEN Universitas Negeri Makassar > KARYA ILMIAH DOSEN
Divisions:	KOLEKSI KARYA ILMIAH UPT PERPUSTAKAAN UNM MENURUT FAKULTAS > KARYA ILMIAH DOSEN KARYA ILMIAH DOSEN
Depositing User:	Abdul Malik
Date Deposited:	02 May 2023 04:30
Last Modified:	02 May 2023 04:30
URI:	http://eprints.unm.ac.id/id/eprint/27853

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