17,18-dihydroxy Montecristin Compound from the Stem Bark of the Soursop (Annona muricata Linn.)

Salempa, Pince and Muharram, Muharram and Dini, Iwan and Taba, Paulina and Ilyas, Asriani 17,18-dihydroxy Montecristin Compound from the Stem Bark of the Soursop (Annona muricata Linn.). International Journal On Advanced Science Engineering Information Technology, 8 (6). pp. 2714-2720. ISSN 2088-5334

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Abstract

Abstract: The development of natural ingredients use for conventional medicine is now in high requirement due to the traditional drugs are reasonably undemanding to be achieved. Annonaceae is one plant family which is usually utilized as medical plants in Indonesia and many other countries. One species of the family which is regularly used as customary medicine is A. muricata Linn which is well-known as soursop that comes from Caribbean, Central America, and South America. Along with the technological advancement, compounds and efficacy of soursop plant becomes popular. Annona muricata Linn. or soursop belongs to the Annonaceae family that is traditionally used to treat various diseases, such as cancer, diarrhea, convulsive, fungal and itching. The purpose of this study was to isolate and purify secondary metabolites of ethyl acetate fraction of the soursop stem bark. Research methods include extraction (maceration), fractionation and BLST test against Artemia salina. The structure of the 17.18-dihydroxy montecristin compound was determined by IR, 1H and 13C-NMR spectra HMBC and COSY. The compound had an activity to the tumor cell of murine leukemia cells P-388 with the IC50 value of 34.05 mg/mL respectively. This study found that the compound of 17.18-dihydroxy montecristin have been isolated from the stem bark of A. Muricata L. which has potential as an anticancer with the IC50 of 34.05 μg/mL.

Item Type: Article
Uncontrolled Keywords: 17.18-dihydroxy montecistin; soursop; Annona muricata Linn, anticancer.
Subjects: KARYA ILMIAH DOSEN
Universitas Negeri Makassar > KARYA ILMIAH DOSEN
Divisions: KOLEKSI KARYA ILMIAH UPT PERPUSTAKAAN UNM MENURUT FAKULTAS > KARYA ILMIAH DOSEN
KARYA ILMIAH DOSEN
Depositing User: S.T., M.T. Faruq Ratuhaji
Date Deposited: 05 Mar 2019 00:49
Last Modified: 26 Jan 2021 07:53
URI: http://eprints.unm.ac.id/id/eprint/12467

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